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Metabolon Selects ESA CoulArray® Technology for Key Metabolomics Studies

Research Triangle Park, N.C., and Chelmsford, MAss., Jan. 23, 2004 - Metabolon, Inc., a pioneer in the area of metabolomics research, announced today that it has decided to adopt the CoulArray® technology from ESA, Inc. as an important component in the company's efforts to identify and monitor small molecule cellular biomarkers of disease and disease treatment. The CoulArray® technology is unique in that it uses a series of highly efficient coulometric electrochemical cells to specifically monitor metabolically active small molecule cellular components.

The CoulArray® system can be used to greatly simplify the inherent complexity of metabolomics samples by filtering out mundane, "house-keeping" cellular components. The unique design and properties of the CoulArray® also facilitate easy data analysis of these types of often highly complex samples. In addition, the CoulArray® offers the advantage of being able to distinguish minute changes in metabolomics patterns and components.

Walter DiGiusto, CEO of ESA, Inc., said, "We are delighted with Metabolon's choice of the CoulArray® for their use in metabolomics studies. Their selection of the CoulArray® demonstrates the utility of ESA technology in metabolomics studies, and represents the latest development in our work with Metabolon to accelerate their operations and expand their bioanalytical capabilities."

John Ryals, CEO of Metabolon, said, "The CoulArray® technology from ESA will be a significant component in our metabolomics technology platform. We are pleased to continue our relationship with ESA as we move forward in this important science."

About ESA Inc.
ESA, Inc., is a leading manufacturer and supplier of analytical instruments for the life science, clinical diagnostic, drug discovery and pharmaceutical industries. Founded in 1968, ESA offers a complete line of HPLC systems, components, and advanced detectors, along with a broad range of analytical services. Contact: ESA, Inc., 22 Alpha Road, Chelmsford, MA 01824. Tel: 978-250-7000. Fax: 978-250-7090. Email: ; Web:

About Metabolon
Metabolon is a leader in the application of metabolomics, a powerful and new scientific approach for the discovery and development of drugs and the early diagnosis of disease states. Seasoned and successful entrepreneurs, as well as scientific pioneers, make up Metabolon's executive management team and boards.

Metabolon's patent-pending technology is poised to dramatically impact drug discovery and development processes by accurately measuring the spectrum of biochemical changes and mapping these changes to metabolic pathways. Metabolon's technology can identify safer compounds for development, shorten the time for drugs to get to market and identify diagnostic markers for earlier disease detection.

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