METABOLOMICS PROVIDES INSIGHT INTO PATHOGENESIS OF DILATED CARDIOMYOPATHY
RESEARCH TRIANGLE PARK, N.C. (January 6, 2011) — Metabolon, Inc., the leader in metabolomics, biomarker discovery and analysis, announces the publication of ďMetabolomic Distinction and Insights into the Pathogenesis of Human Primary Dilated CardiomyopathyĒ, in the European Journal of Clinical Investigation. Metabolonís non-targeted biochemical profiling (metabolomics) platform was used to identify biochemical biomarkers of primary dilated cardiomyopathy (DCM) and potential therapeutic targets for DCM. The study was carried out by Metabolon scientists in collaboration with A. J. Marin and colleagues from The University of Texas Health Science Center and Texas Heart Institute at Houston.
The advent of ACE inhibitors and ß-blockers has provided significant advances in the treatment of systolic heart failure. Yet, the mortality and morbidity of heart failure patients remains high and the incidence of the disease continues to increase. In this report the authors showed the utility of Metabolonís biochemical profiling technology to provide insight into cardiac metabolism in patients with primary DCM. Changes in several bioactive plasma metabolites related to oxidative stress such as indole-3-propionate (IPA) and stachydrine were measured in DCM patients. In addition, results from Metabolonís global, non-targeted analysis suggest a role of the gastrointestinal tract and gut microflora in heart failure.
Copies of the paper can be accessed: http://onlinelibrary.wiley.com/doi/10.1111/j.13652362.2010.02441
Metabolon is a diagnostics and services company offering the industryís leading biochemical profiling platform. Metabolonís patented platform provides a global analysis of complex biological samples for the discovery of markers and pathways associated with drug action and disease. This metabolomics-driven approach enables the identification of biomarkers useful for the development of a wide range of diagnostics and provides insight into complex biochemical processes such as drug action, toxicology and bioprocess optimization. For more information about Metabolon, please visit www.metabolon.com or contact Matt Zaske firstname.lastname@example.org at (919) 595-2200.